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王玉强是什么 关于王玉强的详细介绍

王玉强,男,博士,暨南大学药学院教授,博士生导师。 王玉强教授从事DNA-minor groove binding 药物CC-1065衍生物的研究多年, 他的实验室合成了100多个CC-1065衍生物, 其中的YW-053是目前已知抗癌活性最强的少数化合物之一,其体外抗癌活性比临床应用的抗癌药物阿霉素强一百万倍 (. , 8917, 1995)。王玉强教授在美国首次GMP合成治疗老年痴呆药物 memantine,作为核心成员,其团队在美国将memantine 成功开发。Memantine2003年先后在欧美上市,2011年在日本上市,2013年在中国上市。Memantine 2007年的销售额达10亿美元, 正式成为“重磅炸弹”级药物。

人物经历

1981年毕业于山东师范大学化学系,获学士学位;

1987年获美国University of Texas Health Science Center at Houston and M. D. Anderson Cancer Center博士学位。 随后进入美国耶鲁大学 (Yale) 医学院和加拿大阿尔伯特大学 (University of Alberta) 做博士后研究。

九十年代初进入美国加州硅谷的生物医药公司从事药物的研究与开发,2005年回国任暨南大学教授,药学院院长,现任暨南大学新药研究所所长,博士生导师。

2010年获广州经济技术开发区科技领军人才称号。

研究方向

药物研究的第一步是发现有生物活性的化合物,然后是研究这些化合物的作用机理和药理活性。王玉强实验室目前主要从事抗细菌和病毒药物、治疗糖尿病、心血管疾病药物如心肌缺血、神经退行性疾病如老年痴呆和帕金森等疾病药物的设计、化学合成、药理活性与作用机理的研究。

主要贡献

王玉强实验室近年开展了对中药有效成份分子结构进行系统的化学修饰的工作。在中药穿心莲、川芎及丹参有效成份的结构修饰方面已卓有成效,发现了比天然产物疗效更高,毒性更低的新化合物。其中具有独特作用机理和良好治疗效果的治疗缺血性脑中风新药已完成临床前研究。  

主要论文

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55.Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Cui, W.; Wang, L.; Sun, Y.; Lang, M.; Hoi, P. M.; Han, Y.; Wang, Y.; Lee, S. M. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP-induced neurotoxicity via inhibition of mitochondrial de-pendent apoptosis. J. Neuroimmun. Pharmacol. 2013 (advance online DOI 10.1007/s11481-013-9514-0).

56.Guo, B.; Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Lee, S. M.; Wang, Y. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson’s dis-ease in vitro and in vivo. Biol. Pharm. Bull. 37, 274–285, 2014.

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59.Lang, M.; Yan, R.; Wang, Y.; Yu, P. A selective O- and N-acylation protocol for carbamyl chloride. Chin. J. Org. Chem. 2014 (advance online).

60.Cui, Q.; Chen, Y.; Zhang, M.; Shan, L.; Sun, Y.; Yu, P.; Zhang, G.; Wang, D.; Zhao, Z.; Xu, Q.; Xu, B.; Wang, Y. Design, synthesis and preliminary cardioprote-ctive effect evaluation of Danshensu derivatives. Chem. Biol.&DrugDes. 2014 (advance online).

61.Li, S.; Shan, L.; Zhang, Z.; Li, W.; Liao, K.; Li, S.; Yu, P.; Wang, Y. Pharma-cokinetic and metabolism studies of ADTM, a novel Danshensu derivative confers cardioprotection by HPLC-UV and LC-MS/MS . J. Chromatogr. Sci. 2014 (advance online).

62.Xu, L.; Li, Y.; Wan, S.; Wang, Y.; Yu, P. Apocynin nitrone protects rats from LPS-mediated acute lung injury via inhibition of NADPH oxidase. Intl. Immunophar-macol. 2014 (advance online).

63.Du, E.; Liang, Z.; Xu, L.; Sun, S.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary biologic activity evaluation of nitric oxide-releasing andrographolide ana-logues. Chem Pharma Bull. 2014 (advance online).

64.Zhang, Z.; Lai, D.; Wang, L.; Pei, Y.; Zhu, L.; Guo, B.; Xu, L.; Sun, Y.; Xu, L.; Zhou, L.; Sun, Y.; Lee, S-M.; Wang, Y. Neuroprotective effects of the androgra-pholide analogue AL-1 in the MPP/MPTP-induced Parkinson’s disease model in vitro and in mice. Pharmacol. Biochem. Be. 2014 (advance online).  

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